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Nitric oxide (NO) signaling cascade The generation of nitric oxide (NO) catalyzed by endothelial nitric oxide synthase (eNOS) plays a critical role in protecting the vascular endothelium from oxidative and inflammatory insults (27)

SERMs, Selective estrogen receptor modulators

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CAF heterogeneity further complicates this design problem

Abnormally released mtDNA into the circulation or mtDNA-associated NETs are capable of instigating drastic immune responses through the above mechanism not only in systemic inflammatory response syndromes (SIRS) but also in hematological malignancies, and neutrophils are thought to play an essential role in this process (60, 61)