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An analysis of data from the Veterans Health Administration looked at more than 16,000 people with diabetes and presumed MASLD who started a GLP-1 agonist or a different type of diabetes drug between 2006 and 2022

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Through targeted ablation of each population in Glp1r-ires-Cre mice, researchers discovered that only the DVCGLP1R neurons were essential for the efficacy of GLP1R agonists like exendin-4 and semaglutide in suppressing food intake and preventing weight gain

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