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Cagrilintide is a synthetic long-acting amylin analogue a peptide designed to mimic and extend the biological activity of amylin (also known as islet amyloid polypeptide, IAPP), a 37-amino acid pancreatic hormone co-secreted with insulin from pancreatic beta cells
An orally-available selective nonpeptide SST5 agonist, CRN02481, has been shown to suppress insulin secretion and increase glucose levels in both oral glucose tolerance tests and a sulfonylurea model of hyperinsulinism ( -/- mouse model of CHI ( Conclusions The biology of SST receptors and ability of SRLs to activate specific receptor subtypes to reduce excess insulin is important in the understanding of the pathobiology and treatment perspectives in CHI
It is not approved for human or veterinary use and no therapeutic claims are made
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