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Beyond weight, the SELECT trial (N=17,604) published in the New England Journal of Medicine in 2023 showed that semaglutide 2.4 mg reduced major adverse cardiovascular events (MACE) by 20% compared to placebo in adults with overweight or obesity and established cardiovascular disease, over a median follow-up of 39.8 months (HR 0.80 to 95% CI 0.72 to 0.90)

and modifying underlying pathophysiology or dysfunction

doi: 10.1097/HEP.0000000000000323 87

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Metabolic Health Optimization Regular allulose consumption may support overall metabolic wellness: Reduces risk of metabolic syndrome Supports cardiovascular health through multiple mechanisms Helps maintain energy levels without sugar crashes Promotes healthy body composition 4