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Matt Kaeberlein (UW Medicine, Optispan) observed: Expecting a single drug to meaningfully alter the course of Alzheimers once cognitive decline is underway is an extraordinarily high bar. The EVOKE population already had MCI or mild dementiameaning pathological cascades were well-established

Antibiotics (Most Important Group): Trimethoprim-Sulfamethoxazole (Bactrim, Septra) Sulfadiazine Sulfisoxazole Sulfasalazine (used in rheumatoid arthritis, ulcerative colitis) 2

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They have been developed so that the active substance is stable and well-absorbed from the digestive tract, eliminating the need for injections