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There was no statistical significance in the development of ION between cohorts, 1-year hazard ratio of 0.872 (95% CI: 0.6271.212), 3-year HR of 1.002 (95% CI: 0.7921.268), and 5-year HR of 0.978 (95% CI: 0.7891.211)

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Although normal electron transport in mitochondria involves four-electron reduction of O 2 to water, partial reduction reactions occur under physiological conditions, causing release of superoxide anion and hydrogen peroxide (H 2 O 2 )

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These microbial-derived molecules act as pathogen-associated molecular patterns (PAMPs), activating pattern recognition receptors (PRRs) on peripheral immune cells and brain-resident microglia