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Achieving specificity is the biggest challenge in the development of Nrf2 inhibitors

In addition to the usual dietary recommendations, it is reasonable to propose to concerned people a product whose interest is demonstrated

For instance, erastin and RSL3 selectively affects the glutathione antioxidant system, which leads to increase lipid peroxidation and causes the death of cancer cells [29, 87]

Hepatocyte-specific inhibition of NF-kappaB leads to apoptosis after TNF treatment, but not after partial hepatectomy

Therefore, the intracellular levels of GSH are regulated by the negative feedback of GSH itself on the GCL enzyme (5557) and by the availability of the amino acid L-cysteine (58)