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PMC+2PMC+2 The authors conclude that while laboratory results are intriguing, human safety is unknown, and unregulated compounding introduces risks of contamination, mislabeling and dose inconsistency

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In individuals with obesity without T2DM, SURMOUNT- 1 evaluated the safety and effectiveness of tirzepatide 5, 10, and 15 mg once weekly in comparison to a placebo when paired with a 500 kcal/day deficit diet and recommendations for 150 min of weekly exercise [118]