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People may be at an increased risk of B12 deficiency if they: Consume a vegans or strict vegetarian diet Have eating disorders such as anorexia or bulimia Take antacids or diabetes related drugs that may interfere with B12 absorption Have a history of alcoholism Have a family history of pernicious anaemia Are diagnosed with anaemia Have Crohns disease, irritable bowel or any disease causing malabsorption of nutrients Have an autoimmune disease, such as type 1 diabetes, SLE, Addisons disease Are women with a history of infertility or multiple miscarriages Each ml contains 1000mcg of hydroxocobalamin Injectable water Suitable for vegans and vegetarians

10.1161/CIRCRESAHA.121.318061 9 Brandes RalfP.IngridF.RudiB

Meddings, J

FDA cites potential immunogenicity from aggregation and peptide-related impurities and states that human safety data are limited