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When stacking, many clinicians reduce each peptide by 2550 % from its standalone dose because of the additive effect

In vitro studies suggested that genistein treatment of human keratinocytes and fibroblasts modulates glutathione content and reactive oxygen species release, endothelial/inducible (e/i)NOS dependent nitric oxide release, MMP expression, and mitochondria membrane potential through mechanisms involving p38 MAPK, AKT and ERK1/2 as downstream signaling associated with membrane ERs and GPER, as well as by increasing SOD activity and BCL2 expression in endothelial cells (Savoia et al., 2018

The therapeutic dose is approximately 300-fold below the toxic threshold according to animal studies

In addition, partial oxygen pressure in RPE is high due to anatomical proximity to choriocapillaries 5,6,7

Ambudkar, I