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Long-term human safety data is limited for both

In a 2013 study, Hsieh and colleagues gave hypogonadal men on testosterone replacement 500 IU of HCG intramuscularly every other day

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Patients taking certain medications (e.g., chloramphenicol may reduce the effectiveness of B12 therapy) or with risk factors for B12 deficiency (metformin use, proton pump inhibitors, nitrous oxide exposure, vegan diet) should discuss these with their healthcare provider