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Adherence and persistence research abstract Learn more about the methodology of Primes research study, Year-Two Real-World Analysis of Glucagon-Like Peptide-1 Agonist (GLP-1) Obesity Treatment Adherence and Persistency. Cost-of-care data Individuals without diabetes who started a GLP-1 medication for obesity experienced an average of $4,206 higher cost of care in their second year compared to similar members who did not take a GLP-1 drug for obesity