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Patients typically have diffusely dry skin, indicating increased transepidermal water loss [3]

10.1016/S0006-8993(98)00584-8 99 ThieleT

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Although conclusive identification of ferroptosis in vivo is challenging, several salient and very well established features of neurodegenerative diseases are consistent with ferroptosis, including lipid peroxidation, mitochondrial disruption and iron dysregulation