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In this case, the B12 shots have started to heal the damaged neurons myelin sheath, but the neural network in which the healed neuron is in, is in a super sensitive state (with extra receptors), so the patient may feel pain or other unpleasant sensations

Metabolism of 1-chloro-2,4-dinitrobenzene in isolated perfused rat and guinea pig livers

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Thus, the increments in the affinity and activity owing to Glu 22 could be caused by a carboxyl group on Glu adding an extra binding site for the receptor

It may provoke neuropathy symptoms at first