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Higher relative abundance of proinflammatory bacteria like Eggerthella, Atopobium was found to be increased, and decreased relative abundance of Faecalibacterium in the subjects with MDD (Knudsen et al., 2021)

OTUD1 activates caspase-independent and caspase-dependent apoptosis by promoting AIF nuclear translocation and MCL1 degradation

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The main cerebral target for THC is type-1 cannabinoid receptors (CB1R), which are widely expressed in the brain and regulate various functions including neurotransmitter release, neuro-astroglial communication, and cellular bioenergetic processes [29,30,31,32]