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Abstract There is an urgent need to develop novel compounds that prevent the deleterious effects of opioids such as fentanyl on minute ventilation while, if possible, preserving the analgesic actions of the opioids

The overall structure of the DDD complex demonstrated that the N-terminal helix-loop-helix of DET1 binds to the cleft between the BPA and BPC domains of DDB1, similar to other reported DCAF structures (Supplementary Figs