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In the STEP and SURMOUNT trials for semaglutide and tirzepatide respectively, weight loss curves generally began to flatten between weeks 36 and 60, reflecting the physiological set point adaptation that occurs as appetite suppression becomes partially offset by metabolic adaptation

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The longer needles create more significant micro-injury requiring extended recovery

(PubMed) Tsuji PA, Santesmasses D, Lee BJ, Gladyshev VN, Hatfield DL

Expert Opin Drug Metab Toxicol 17:153169 Rosenkranz G (2020) Exploratory subgroup analyses in clinical research: Wiley 2020 Manson LE, van den Hout WB, Guchelaar H-J (2021) Genotyping for HLA risk alleles to prevent drug hypersensitivity reactions: impact analysis