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As reported online in Cell Metabolism on Sept

Without this substance, lipids could not be broken down, consequently lipolysis would also be discouraged, as the human body is a perfect machine that regulates itself, avoiding metabolic dysfunction

However, the potential risk of severe but rare adverse events, such as pancreatitis and medullary thyroid carcinoma, along with its high cost, remains significant considerations for clinical decision-making and patient adherence [77, 79]

Additionally, incretin therapies can have overbearing negative side effects including hypoglycaemia (often in combination with other glucose-lowering treatments), nausea, vomiting, gastrointestinal upset (including diarrhoea) and injection site reactions that contribute to therapy discontinuation ( TABLE 1 Incretin therapy studies including percentage of participants who failed to reach the desired endpoint

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