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Replacement of proteins by the artificial small-sized dimeric macrocycles seems to have advantages for drug development, such as production by chemical synthesis and amenability to chemical modifications for the control of pharmacokinetics, protease resistance and drug delivery, and such controlled properties should be carefully evaluated in future research and development

BPC-157 appears to be an exception in animal studies: it retains biological activity when administered intragastrically in rats and mice, including in colitis and ulcer models

Copper-peptide complex is stable

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