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Semaglutide drives beta cell survival and proliferation through sustained GLP-1R-mediated PI3K-Akt anti-apoptotic signalling, PDX-1 transcription factor activation, and beta cell neogenesis biology , with the one-week pharmacokinetic window of Semaglutide enabling chronic beta cell GLP-1R trophic stimulation paradigms not achievable with shorter-acting incretin research compounds

Common Side Effects While semaglutide is generally well-tolerated, some common side effects include nausea, vomiting, diarrhea, and abdominal discomfort

Others overlap slightly to avoid appetite rebound

Semaglutide, available in both injection and oral pill forms, mimics the GLP-1 hormone that naturally reduces appetite and supports sustained weight loss

If sleep problems persist or worsen whilst taking Wegovy, it's important to discuss this with your healthcare provider to rule out other causes and explore appropriate management strategies