Secondly, the intestinal metabolism of L-carnitine is thought to generate trimethylamine-N-oxide (TMAO), a compound that has been linked with faster atherosclerosis progression
The SELECT trial, which evaluated semaglutide 2.4 mg against placebo for cardiovascular outcomes in patients with overweight and obesity without type 2 diabetes, showed significant decreases in total cholesterol, LDL-C, and triglycerides and an increase in HDL-C at 39.8 months [48]
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