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The research rationale for studying them together is their complementary, non-overlapping mechanisms rather than shared receptor activity
In the patients who primarily complain of radiculopathy (radiating leg pain) with an stable spine, a decompression surgery may be recommended to remove bone from around the nerve root to give the nerve root more space
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Some patients report initial improvements in symptoms within 1-2 weeks, while more significant healing typically develops over 4-8 weeks
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