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[171] A 2025 observational study reported a modest increased risk of a serious eye condition in people with diabetes taking glucagon-like peptide-1 (GLP-1) receptor agonists

This also led its drug manufacturer, Novo Nordisk, to get a higher dose of the active ingredient semaglutide FDA-approved for weight management under the brand name Wegovy

Blundell, J., Finlayson, G., Axelsen, M., Flint, A., Gibbons, C., Kvist, T., & Hjerpsted, J

In clinical trials, severe GI adverse reactions were reported more frequently among patients who received Ozempic injection (0.5 mg 0.4%, 1 mg 0.8%) than placebo (0%)

Semaglutide without glycine still works