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These limitations may partially explain the discrepancy between promising preclinical results and the limited success observed in clinical trials

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Thus, hydroxyproline-containing dipeptides and tripeptides in the lumen of the small intestine are transported intact into enterocytes (absorptive epithelial cells) by H + gradient-driven peptide transporters (Fig

J Biol Chem 282:83438355 Chandhok G, Schmitt N, Sauer V, Aggarwal A, Bhatt M, Schmidt HH (2014) The effect of zinc and D-penicillamine in a stable human hepatoma ATP7B knockout cell line