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For instance, Erastin, a small molecule anticancer drug, functions by directly inhibiting System Xc and disrupting cellular antioxidant processes, thereby inducing tumor cell death

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The trial results enable the pharmaceutical to pursue regulatory approval to be able to commercialize the drug for cardiovascular-related indications

This could be due to a Zn-induced inhibition of phosphatase activity, leading to Mitogen-activated protein kinase (MAPK) and activator protein-1 (AP-1) activation, resulting in the enhanced IL-8 expression [140]