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Sources Changes in lean body mass with glucagon-like peptide-1-based therapies and mitigation strategies Diabetes, Obesity and Metabolism, Neeland et al., 2024 Muscle Mass and Glucagon-Like Peptide-1 Receptor Agonists: Adaptive or Maladaptive Response to Weight Loss

Chowdhury SR, Saleh A, Akude E, Smith DR, Morrow D, Tessler L, et al

Gastrointestinal side effects remain the most common (which tend to fade over time), but serious adverse events are rare

Our teams observations show that this mechanism directly impacts the energy balance within cells, encouraging them to burn fat for fuel rather than store it