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Neuropsychopharmacology 2005;30:173540

Particularly noteworthy is that FOXO4 influences not only lifespan but also the quality of aging through its interaction with the protein p53commonly referred to as the "guardian of the genome." This interaction regulates whether cells remain in a senescent, metabolically inactive state or undergo programmed cell death (apoptosis)

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These promising results were more pronounced at the high dose of EMPA (3 mg/kg) than at the lower dose (1 mg/kg), which indicated that EMPA may exert its effects in a dose-dependent manner