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96 While SIRT1 in adipose tissue significantly affects systemic insulin sensitivity, its direct role in non-parenchymal liver cells in glucose metabolism remains unclear and is likely mediated through immune and inflammatory signaling pathways

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Exhibiting a favorable safety profile with manageable mild-to-moderate gastrointestinal adverse effects, it emerges as a promising novel therapeutic option for overweight and obese individuals in China, particularly those presenting with comorbidities, such as MASLD, hyperuricemia, or dyslipidemia

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