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Symptoms of this disorder often start during infancy and can include drowsiness, seizures that may be accompanied by involuntary jerking muscle movements of the arms, legs or head (myoclonic seizures), and intellectual disability

This alteration suppressed GATA3 expression via the bile acid-Takeda G protein-coupled receptor 5(TGR5)-cyclic adenosine monophosphate (cAMP) signaling pathway, leading to a marked ~90% reduction in IL-22 secretion from intestinal group 3 innate lymphoid cells (ILC3s), which subsequently induced insulin resistance, ovarian dysfunction (characterized by increased follicular cysts and decreased corpora lutea), and impaired fertility (82)

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Scheibe and Dietz 2012