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For the identification of druggable targets, we considered three classes of enzymes: tier-1 targets, tier-2 targets, and other enzymes. Tier-1 targets correspond to enzymes whose knockout impedes viral replication while having a minimal impact on the simulated cellular viability

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Glp1r fl/fl mice treated with mGIPR-Ab/P1 also had lower total fat and inguinal WAT weights compared to vehicle, whereas Glp1r Wnt1/ mice treated with mGIPR-Ab/P1 showed no significant differences (Fig