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Further analysis of signaling pathways confirmed that PD effectively upregulated endogenous TGF-/Nodal signaling and downstream Smad2/3 transduction, while concurrently downregulating BMP signaling, leading to robust DE formation

Furthermore, within the trauma-exposed group, higher prefrontal GABA levels retained a marginally significant association with reduced CBF levels after excluding four potential outliers ( = 0.240, P = 0.071)

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