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645 Protoplasmic (but not fibrous) astrocytes protect against -synuclein toxicity by removing this latter through endocytosis, 646,647 and hence astrocytic atrophy reduces neuroprotection

It also reduces oxidative stress that causes tanning and hyperpigmentation and promotes free radicals to shield the skin from further damage

Role of Mitochondria in Ferroptosis

Since GSH is also an antioxidant that can scavenge ROS [71,72], the increased GSH consumption may result in decreased resistance to oxidative stress in the liver of the Aldh2*2 KI mice