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Moreover, in vitro cultures offer additional advantages due to their ease of handling, allowing them to be modulated using various treatments 7,8

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In all these studies, the reduction in osteoclastogenesis was accompanied by a dopamine-mediated reduction in osteoclastic markers (c-Fos, Nfatc1, Trap, Ctsk) that was generally found to be mediated through D2-like receptor signaling

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