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There is evidence here

Topical anti-aging effects are biologically plausible because collagen, glycosaminoglycans, skin elasticity, fibroblasts, and extracellular matrix remodeling are all directly relevant to skin aging [2], [4], [12]

During a live study on gastric cancer (GC), the secretion of HGF by CAFs enhanced the presence of interleukin-6 receptor (IL-6R) in MET non-amplified GC cells via the HGF/c-MET/ERK1/2 signaling pathway [49]

Proper storage at 20 C is recommended to preserve peptide integrity