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In mice, 3-AR receptors mediate cold-induced thermogenesis (223) and pharmacological activation of 3-ARs acutely stimulate lipolysis leading to two-fold increase in energy expenditure, a dramatic ten-fold increase in insulin levels, and 4050% reduction in food intake (98)

This mechanism explains why PT-141 works differently than anything else

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Only 4.2% of participants discontinued due to side effects after week 24, indicating that side effects become manageable or resolve entirely for the vast majority who continue treatment