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Special Caution: While using the dark spot corrector, sun exposure should be minimized as the skin can be darkened again

Lactate inhibits 2-oxoglutarate-dependent prolyl hydroxylases (PHDs) (mainly PHD2), which in turn prevents Von Hippel Lindau tumor suppressor (VHL)-mediated ubiquitination of hypoxia-inducible factor 1 (HIF-1) and its proteasomal degradation, thus stabilizing HIF-1

The mechanism involves upregulation of VEGF expression a key growth factor in new blood vessel formation and activation of ERK1/2 signaling pathways that drive cell proliferation, migration, and angiogenesis

Similar changes were noticed when measuring trunk fat, however, waist circumference did not significantly change

When the gut lining becomes compromised, it can lead to a wide range of issues including inflammation, poor digestion, and systemic health disruptions