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The theory of the origin of sleep which has gained the widest credence is the one that attributes it to anemia of the brain The idea behind this supposition has been that, as the day draws to an end, the circulatory mechanism becomes fatigued, the vasomotor center exhausted, the tone of the blood vessels deficient, and the energy of the heart diminished, and thus is the circulation to the cerebral arteries lessened. NATURE, May 5th, 1898

Moreover, asparagine stimulated the mTORC1 pathway, which promoted the expression of thermogenic genes and key enzymes in glycolysis, thereby affecting systemic energy homeostasis [22]

doi: 10.1681/ASN.2020010079 227

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