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Specifically, under HFD conditions, SLC25A1 inhibition promoted FAO by deacetylating carnitine palmitoyltransferase 1A and reduced glucose oxidative catabolism by triggering the acetylation-induced inactivation of pyruvate dehydrogenase E1, which caused enhanced glucose uptake and storage in the liver, and activated the SIRT1/PGC1 pathway to enhance oxidative phosphorylation for energy production

Titles and abstracts were screened for relevance by two investigators (G.F.R

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10.1523/jneurosci.1650-20.2020 23

You might feel more anxious, moody, and have trouble focusing