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The rats in the OA-1, OA-5, OA-10, OA-20 and OA-28 groups received an intraarticular injection of MIA and were sacrificed after 1, 5, 10, 20 and 28 days, respectively after intraarticular injection of MIA

Hyaluronic acid hydrates while phytoceramides lock in moisture

Two subjects did not receive metformin

Animal studies have raised concerns about fetal development risks