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Most of these upregulated pathways were downregulated by TS, including arginine biosynthesis, aminoacyl-tRNA biosynthesis, GABAergic synapse, D-amino acid metabolism, central carbon metabolism in cancer, and protein digestion and absorption, among others (Figure 3D)

Lyall et al., 2017[28]).The most recent spike in diagnosis could have been attributed to the publication of Diagnostic and Statistical Manual of Mental Disorders, 5 th ed

Acute symptoms such as fatigue may improve relatively quickly, whereas neurological symptoms like paraesthesia (pins and needles) or cognitive difficulties typically require longer treatment courses