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Subsequent investigations have demonstrated that histone Kla can directly enhance the transcription and expression of stable genes by modulating chromatin accessibility

Histidine, a key component of L-carnosine, plays an important role here because it acts as a shield against advanced glycation end (AGE) products, which can negatively impact our cells over time

Such increases appear to be closely linked to MetS, type 2T2DM, and CVD risk (12, 14)

For within-subject comparisons over time, the multivariate approach to repeated measures or the Mann-Whitney U test was applied because Mauchlys test indicated a violation of the sphericity assumption