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Rho GTPase activity and actin cytoskeleton dynamics are sensitive targets for the reversal of acquired resistance in GBM tumors with wild-type p53

doi:10.1016/j.molmet.2019.09.010 Forst T, De Block C, Del Prato S, et al

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For example, FASN-derived palmitate targets MHC-I for lysosomal degradation via palmitoylation, disrupting CD8 + T-cell recognition [136]

From my perspective, that sense of scalability is extremely important for entrepreneurs entering a high-margin category like peptide serums, where early traction can sometimes accelerate growth unexpectedly