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In the MASLD trial, the improvements in HOMA2-IR and fasting insulin were dose-dependent and closely associated with the reduction in liver fat and liver de-fatting via glucagon-receptor agonism is at least partially a drug-specific action rather than a pure consequence of scale weight loss

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About 61% of GLP - 1 users in the study were taking the drugs to treat type 2 diabetes, while about 39% of users generally younger, wealthier and fewer clinically obese users were using them to manage their weight