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Finally, the increasing off-label use of GLP-1 RAs for weight loss in non-diabetic individuals may further exacerbate access limitations and drug shortages, potentially disadvantaging patients with T2DM

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As previously noted, there are data demonstrating acinar cell activation and suggesting increased PanIN proliferation in response to GLP-1RAs

Over time, due to DNA replication and oxidative stress, telomeres shorten

Discussion With the popularity of GLP-1 RA medications and challenges in access and insurance coverage, we will continue to monitor prescribing and dispensing trends over time