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Edited by Professor Massimiliano Agostini Supplementary information Rights and permissions Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made

Early intervention at the first sign of returning symptoms prevents full relapse

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15 GPx links two GSH molecules through a disulfide bridge to form GSSG and, during this process, H 2 O 2 is reduced to water and lipid hydroperoxides to their corresponding alcohols