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We then used Molecular Operating Environment (MOE) software to model the covalent binding of ACE with PCBP1/2 via its cysteine residues

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Furthermore, in line with the beneficial effects of RAS blockers, researchers have also shown that the administration of empagliflozin, a SGLT2i, reduced the expression of IL-6, CCL2, and NF-B in the kidneys of diabetic Akita mice, as well as in cultured kidney tubular cells exposed to high glucose (152, 159)

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A pediatric endocrinologist may consider off-label use in rare cases of severe obesity with medical complications, but this requires careful risk assessment and informed consent