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Furthermore, because both can lead to a decrease in blood pressuresemaglutide through weight loss and metabolic changes, and spironolactone as its primary functionpatients may experience lightheadedness or dizziness if their blood pressure drops too low

Oral semaglutide aims to provide the benefits of existing GLP-1 receptor agonists, without the requirement for daily or weekly injections

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Weight regain commonly occurs when discontinuing either medication, as the underlying appetite and metabolic changes return toward baseline

The goal is manageable hunger that allows for controlled eating, not a complete absence of hunger signals