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Specifically, increased expression of AMPA receptors in hypoxic white matter sensitizes microglia to glutamate, leading to a regulatory response that reduces protective IGF-1 release, while increasing the release of inflammatory mediators (Sivakumar et al., 2010)
A study by Xu et al
Antioxidants refer to a whole class of molecules (including certain vitamins, minerals, compounds found in plants, and some compounds formed in the body) that share the same goal of protecting the body and the immune system against oxidative stress
Individuals with ASD are reported to have elevated glutamate levels in the amygdala and hippocampus complex, supporting this excitotoxicity link (Page et al., 2006)
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