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The high price of its blockbuster and intermittent shortages then prompted the FDA to grant permission for pharmacies to compound generic semaglutide to ensure diabetics had continued access to life-saving supplies, a move that inadvertently fuelled a black market boom

For major adverse liver events analysis, person-trials with a history of outcome events were excluded (unweighted N = 6,067,447)

BMJ 2008;336:1177-80.ArticlePubMedPMC 159

2) Which weight-loss GLP-1 brands are impacted?Wegovy, Zepbound, Saxenda are listed as not covered for weight loss starting 1/1/2026

These include improvements in cardiovascular outcomes, making it particularly relevant for patients with type 2 diabetes who are at higher risk of heart disease. Such benefits have positioned semaglutide as a comprehensive metabolic therapy rather than a single-purpose drug