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At year 1, superior weight loss with liraglutide (7.8 kg) over both placebo (2.0 kg) and orlistat (3.9 kg) was demonstrated

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Different from a 2.5-turn -helix of ECL1 in both activated GLP-1R and GCGR, the ECL1 of GLP-2R partially unwinds vertically in line with TM2 and TM3, providing additional interactions not seen in its counterparts (Figs

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